Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis
نویسندگان
چکیده
منابع مشابه
Mefloquine chemoprophylaxis of soldiers on the Thai-Cambodian border.
Chemoprophylaxis of malaria on the Thai-Cambodian border is difficult due to the high level of drug resistance. Thirteen separate companies of Royal Thai Marine Militia were placed on 250 mg weekly mefloquine chemoprophylaxis from August 1989 to January 1990. A mean number of 722 soldiers received two or more doses of mefloquine per month for the five month study. The medication was well tolera...
متن کاملMefloquine use, psychosis, and violence: A retinoid toxicity hypothesis
Mefloquine use has been linked to severe gastrointestinal and neuropsychiatric adverse effects, including cognitive disturbances, anxiety, depression, psychosis, and violence. The adverse effects of the drug are thought to result from the secondary consequences of hepatocellular injury; in fact, mefloquine is known to cause a transient, anicteric chemical hepatitis. However, the mechanism of me...
متن کاملDo travelers really take their mefloquine malaria chemoprophylaxis? Estimation of adherence by an electronic pillbox.
BACKGROUND Nonadherence to chemoprophylaxis could explain why some travelers get malaria. Adherence is notoriously difficult to assess, and most studies have been conducted using questionnaires. This study aims at assessing continuous adherence more accurately with the help of an electronic pillbox. METHODS Adult travelers to sub-Saharan Africa had to fill a questionnaire on demographic and t...
متن کاملMefloquine as a potential drug against multidrug-resistant tuberculosis
Support statement: This work was supported by the State of New Mexico (appropriation from the Tobacco Settlement Fund), from the National Institutes of Health (P50HL107165 for B. Celli and Y. Tesfaigzi, RO1 HL068111 and ES015482 to Y. Tesfaigzi, R01CA164782 for Y. Tesfaigzi/S.A. Belinsky, R01 CA097356 for S.A. Belinsky, HL105339, HL114501, AI111475 for C.A. Owen, FAMRI CIA 123046 for C.A. Owen)...
متن کاملMefloquine as a potential drug against multidrug-resistant tuberculosis.
In the article by ALSAAD et al. [1] in a recent issue of the European Respiratory Journal the authors reviewed six drugs with antimicrobial activity against Mycobacterium tuberculosis (phenothiazine, metronidazole, doxycycline, disulfiram, tigecycline and co-trimoxazole) which are not listed in the World Health Organization guidelines on multidrug-resistant tuberculosis (MDR-TB) treatment, but ...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2009
ISSN: 1475-2875
DOI: 10.1186/1475-2875-8-188